Cardio Support

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Aged black garlic is Mother Nature’s richest source of s-allylcysteine (SAC) and s-allylmercaptocysteine (SAMC), unique amino acid derivatives that have potent antioxidant and cardioprotective effects. While fresh garlic is suggested to be health-promoting due to its allicin content, which imparts the characteristic taste and smell of garlic, new evidence hints that aged black garlic is a stronger antioxidant [1]. 

As garlic ages, the allicin content naturally converts to antioxidant compounds, notably SAC and SAMC, which are vasodilators of coronary arteries [2]. There’s also clinical evidence that aged black garlic extract can significantly improve blood lipid profiles by increasing HDL (“good”) cholesterol and reducing alipoprotein B, the “backbone” of LDL (“bad”) cholesterol  [3].

MegaNatural®-BP is a patented grape seed extract standardized for a specific class of antioxidants known as proanthocyanidins (PACs). Several clinical trials demonstrate that PACs in grape seeds promote blood flow and healthy blood pressure levels by bolstering nitric oxide production and reducing inflammatory markers [6, 7]. 

Grape seed PACs also appear to attenuate symptoms of metabolic syndrome by strengthening intestinal function and modulating the gut microbiome [8, 9].

Coenzyme Q10 (CoQ10), also known as ubiquinone and ubiquinol, is an important endogenous biological redox cofactor that is essential for electron transport chain function and, consequently, energy production. As we age, cellular levels of CoQ10 decline precipitously and are implicated in the onset and progression of disease states, such as heart disease and Alzheimer’s disease [10]. 

By converting between its oxidized and reduced forms (ubiquinone and ubiquinol, respectively), CoQ10 sequesters and neutralizes reactive free radicals generated by the electron transport chain, thereby protecting mitochondria and cells from oxidative stress [11]. It’s suggested that supplementing with CoQ10 can help replenish cellular levels as we grow older, which may confer a therapeutic/protective effect [12]. 

Magnesium is an essential cofactor (think: “assisting molecule”) for an estimated 300+ biochemical reactions throughout the body [15]. For example, magnesium is a major constituent of bone minerals and a mediator of immune function, skeletal muscle contraction, nerve impulse transmission, and adrenal function, the latter of which directly modulates blood pressure. 

Recent studies suggest that the average person does not meet the recommended daily intake for magnesium and may be at risk of (sub)clinical hypomagnesemia [16, 17]. Therefore, bioavailable magnesium supplementation is becoming an important staple for overall health and wellness.